Anti-calcification Effects in Decellularized and Variously Fixed Bovine Pericardium
نویسندگان
چکیده
منابع مشابه
Effects of gamma irradiation on mechanical behavior and calcification of glutaraldehyde-fixed bovine pericardium.
OBJECTIVE To evaluate the effect of gamma irradiation on glutaraldehyde-fixed bovine pericardium. METHOD Glutaraldehyde-fixed bovine pericardium was exposed to gamma radiation (doses from 0 to 10000 Gy). Six samples from each of nine groups were evaluated by optic microscopy, and shrinking and mechanical tests and the denaturation temperature was determined. Additionally, they were subcutaneo...
متن کاملAnti-calcifying treatment of glutaraldehyde fixed bovine pericardium: comparisons and evaluation of possible synergic effects
Objective: To evaluate a possible synergic effect of the most promising anti-calcifying agents investigated in the literature by sequential treatment. Method: Glutaraldehyde-fixed bovine pericardium was treated by: heating to 50o C, 80% ether, 0.125% chitosan, heparin, NaBH4 and 4% formaldehyde. Samples were evaluated by optic microscopy, shrinking and mechanical tests and implanted subcutaneou...
متن کاملComparison between the decellularized bovine pericardium and the conventional bovine pericardium used in the manufacture of cardiac bioprostheses
Introduction: In this paper, our objective was to compare the decellularized and conventional pericardium mechanical resistance and also its capability of inducing inflammatory response in an animal experimental model. Methods: In order to study these properties, we divided the pericardia into two groups: Group I pericardium conventionally treated with GTA and Group II – pericardium previously ...
متن کاملCalcification of decellularized and alpha-galactosidase-treated bovine pericardial tissue in an alpha-Gal knock-out mouse implantation model: comparison with primate pericardial tissue.
OBJECTIVES Immune reaction against the α-Gal(Galα1,3-Galβ1-4GlcNAc-R) epitope is known to be one of the important factors for calcification of bioprostheses. The genetically manipulated α-Gal knock-out (KO) mice lacking the α-Gal epitope and containing anti-α-Gal antibodies may simulate an immune response against xenoantigens in primates including humans. The aims of this study were (i) to comp...
متن کاملPolyethylene glycol-grafted bovine pericardium: a novel hybrid tissue resistant to calcification.
Calcification is a frequent cause of the clinical failure of bioprosthetic heart valves fabricated from glutaraldehyde pretreated bovine pericardium (GATBP). An investigation was made of the grafting of different molecular weight polyethylene glycol (PEG 600, 1500, 4000 and 6000) via glutaraldehyde (GA) linkages to bovine pericardium (BP) and of their stability and calcification. The process of...
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ژورنال
عنوان ژورنال: The Korean Journal of Thoracic and Cardiovascular Surgery
سال: 2010
ISSN: 2233-601X,2093-6516
DOI: 10.5090/kjtcs.2010.43.3.235